Beijing on March 8, internationally renowned academic journal "Nature Communications" published online diffuse gastric cancer proteomic research Military Academy of Military Medical Research Institute and the Cancer Hospital of Peking University jointly carried out。 This achievement shows that the protein can provide important and comprehensive information for clinical science, there is likely to be directly carried out the precise basis for future medical care for patients with gastric cancer。
  Science and Technology Daily reporter interviewed 16 after the relevant parties understand that this research, led by Academician He Fuchu marks the "China Human Proteome Project", to capture the first seat to the protein component type as the main reference for precision medicine " city ", indicates that 'precise medical proteomics-driven era' coming。
  The "Gastric Cancer Gastric Cancer" accurate diagnosis "stomach cancer diagnostic analysis techniques like the use of proteomic tumor 'portrait'。
"National Center for Protein Science Academy of Military Medical Renqin Jun introduced himself master of research results," by proteomic analysis techniques, we can give as like a tumor tissue and healthy tissue a painting of each patient, comparing different people 'two portraits', find the difference between a healthy person's 'looks' and different types of tumors 'appearance' in order to determine what kind of suffering from the disease。
"Statistics show that China's annual new cases of stomach cancer are about 680,000 cases, accounting for about half of incident cases globally。 Currently, according to the clinical pathological features into the gastric intestinal, diffuse and mixed, which diffuse the worst prognosis, and the lack of effective targeted treatment, known as "gastric cancer and gastric cancer."。
  From the beginning of 2014, a joint team of Qin Jun Shen Lin Beijing Cancer Hospital team started a large-scale analysis of gastric cancer samples, to diffuse gastric cancer "portrait"。
They screened to meet paraneoplastic tissue samples and paired cancer research requirements from the 2451 cases of gastric cancer samples。 Samples were analyzed by mass spectroscopy, we identified 11 340 different gene products, covering all possible protein expressed by tumor cells and the tumor microenvironment。
By next gastric cancer tissues and whole protein expression profile of cluster analysis, they will diffuse gastric cancer is divided into three closely associated with survival prognosis and chemosensitivity molecular subtypes, selected 23 candidates associated with the prognosis of gastric cancer protein drug target, and is expected to replace protein with a small number of whole protein expression profiling mode, determines whether the diffuse gastric cancer for which one of the three molecular subtypes, thus laying a solid foundation for clinical application。
  Studies have shown that diffuse gastric cancer patients with these three types, there are significant differences in postoperative chemotherapy and survival duration。
"The proteome study accurately distinguish found associated molecular typing and prognosis。
The next step for different types of diffuse gastric cancer, or other types of cancer, we will be able to make accurate diagnosis and treatment, which is precisely the implementation of targeted therapy after accurate diagnosis。 '' China Human Proteome Project 'chief scientist, Chinese Academy of Sciences, Academy of Sciences He Fuchu military representation。
  With "innovative painting techniques" to identify the therapeutic target group is the study of the laws of life from a holistic point of view of science, just as the five senses together, in order to identify the person's appearance。 Proteomic and genomic there are differences: genome reflects the inherent genetic information, like the appearance at birth; and proteome reflects external function information, looks like people of different ages。 Of course, we can speculate that looks at different ages by appearance when a person is born, but the actual appearance will be affected by various external factors。
  "This is like the original that need painting portraits in pencil and sketched out a rough outline and then coated with paint, sketch and later found to be a new art form。
Constitute the body's various organs genome is the same, but the performance of different organs vary in form and function, one of the key decisions in the proteome。
Proteome is much more complicated than the genome。 "Task Force's expert science channel, does not depend on any genomic information, proteomics can provide an important basis for clinical science。   Jun Qin research team found that some patients can detect gene mutation, but beside carcinoma and cancer was not detected in its corresponding protein expression, indicating that the drug can not play a therapeutic role for this gene mutation。
  "It's like the relationship between pigment and pigment pool。
"Qin Jun said that the genome is like pigment pool, offers a variety of pigments to depict a picture。
While the protein is a pigment of various colors, by the interaction exhibit different colors。
Check the pool alone is missing some paint pigments, may not be able to find which part of the painting produce color。   "We can 'innovative painting techniques', accurately detect the protein expression of cancer and adjacent cancer tissues by big data, to analyze what is the kind of pigment problems, to explore the relevant laws of science, to distinguish between different types of diseases。 By studying the proteome, we can accurately find therapeutic targets, it is possible to find the exact cause of tumorigenesis, and even have a special role through protein, inhibition of cancer cells, tumor treatment。 "He said。   Proteomics will drive accurate medical boom "proteomic technology breakthrough has been made in recent years。 "Qin Jun said, now typically 6 hours or more can be quantitatively to a 6000 gene products, the type of the actual protein expressed within the cell rather, the required number of samples can contain up to 000 cells, about a few cubic millimeters the organization。 This allows the individual to carry out a certain number of proteomic studies of people with the condition, so "China Human Proteome Project" in just four years to basically complete the task of data output of the first stage, which is not until 10 years imagination。
Recently published results of this study are part of the "China Human Proteome Project" of。   Reporters learned from the US-led human cancer genome project (TCGA), in the past decade depicts the genomic variation profiles dozens of tumors, drawn genome "topographic map" of cancer, it has made great for human understanding cancer contributions, also gave birth to the United States of "accurate health plans" and "cancer moon program"。
The post-genomic era proteomics as development in China has been maintained with the international trend goes hand in hand。
Start at the Ministry of Science 863, 973 and the "International Partnership" jointly funded under the 2014 "China Human Proteome Project" trying to understand cancer at the protein the higher dimensions, reveal the molecular mechanism of tumor, finding therapeutic targets。
  He Fuchu Academy of Sciences, said, "China Human Proteome Project" is to give different normal physiology and disease "portrait" that can accurately identify health and disease, the first stage selection than ten kinds of liver cancer, diffuse-type gastric cancer, lung cancer, etc. cancer as the research object, the current output data has been completed, we have moved into the data analysis and results output stage。
The stomach cancer proteomic research molecular typing just the first one, there are a series of follow-up cancer research organs also will follow, will be coming together to form a "precision proteomics-driven medicine" new wave。 Individual therapy, the accuracy of treatment, targeted therapy and other new treatments, therapeutic strategies and ideas will treat large numbers。